PATIENTS’, PHYSICIANS’, NURSES’, AND PHARMACISTS’ PREFERENCES ON THE CHARACTERISTICS OF BIOLOGIC AGENTS USED IN THE TREATMENT OF RHEUMATIC DISEASES

Patients’, physicians’, nurses’, and pharmacists’ preferences on the characteristics of biologic agents used in the treatment of rheumatic diseases

Luciana Scalone,1 Piercarlo Sarzi-Puttini,2 Luigi Sinigaglia,3 Carlomaurizio Montecucco,4 Roberto Giacomelli,5 Giovanni Lapadula,6 Ignazio Olivieri,7,8,† Angela Maria Giardino,9 Paolo Angelo Cortesi,1 Lorenzo Giovanni Mantovani,1 Monica Mecchia9On behalf of the CARA Study Group1Centre of Research on Public Health, University of Milano-Bicocc

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Biological and Immunological Characterization of a Functional L-HN Derivative of Botulinum Neurotoxin Serotype F

Botulinum neurotoxins (BoNTs) can cause nerve paralysis syndrome in mammals and other vertebrates.BoNTs are the most toxic biotoxins known and are classified as Class A Backpacks biological warfare agents.BoNTs are mainly divided into seven serotypes A-G and new neurotoxins BoNT/H and BoNT/X, which have similar functions.BoNT proteins are 150 kDa p

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Cohort-based pan-cancer analysis and experimental studies reveal ISG15 gene as a novel biomarker for prognosis and immunotherapy efficacy prediction

Abstract ISG15, an interferon-stimulated ubiquitin-like protein, plays a multifaceted role in tumorigenesis and immune regulation.This study comprehensively evaluates ISG15 as a prognostic biomarker and predictor of Twin Sleigh Bed with Storage immunotherapy response through pan-cancer bioinformatics analysis and experimental validation.By integrat

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